Generic Abilify (Aripiprazole)
Abilify
Abilify is an antipsychotic drug to relieve symptoms of schizophrenia and bipolar disorder.
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10 mg x 60 pills
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10 mg x 90 pills
$91.99
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15 mg x 30 pills
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15 mg x 60 pills
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15 mg x 90 pills
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20 mg x 30 pills
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20 mg x 60 pills
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20 mg x 90 pills
$181.99
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20 mg x 120 pills
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20 mg x 180 pills
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Product Description
Common use

Abilify is an add-on medication used for the treatment of major depressive disorder, schizophrenia, manic and mixed episodes associated with bipolar disorder in adults and children and adolescents and also of irritability associated with autistic disorder in pediatric patients. The mechanism of action of Abilify is unknown. It shows partial agonism at the D2 receptor, it is also a partial agonist at the 5-HT1A receptor, and also displays an antagonist profile at the 5-HT2A receptor. It has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.



Dosage and direction

Take Abilify once a daily with or without food. The usual starting dose is 10 or 15 mg, later the dose may be increased to achieve the desired effect.



Precautions



This medication was not approved for use in elderly people with psychosis related to dementia-related psychosis due to the risk of death. Antidepressants increase suicidal thoughts or behaviors in some adolescents especially if the dose is changed or during first period of treatment. Abilify was not approved for use in pediatric patients with depression. As Abilify is able impair judgment, thinking, or motor skills do not use is during operating hazardous machinery, including automobiles if you are not sure that Abilify therapy does not affect you adversely. Inform your doctor if you are pregnant, plan to become pregnant or breastfeeding before to take this medication. Avoid drinking any alcoholic beverages during treatment. Avoid overheating and dehydration. Hyperglycemia, or elevated blood sugar, may occur when taking Abilify. If you have diabetes mellitus, monitor your blood sugar levels regularly.



Contraindications

Breastfeeding, hypersensitivity.



Possible side effect

Most common adverse effects include nausea, vomiting, constipation, headache, dizziness, nervousness, sleeplessness, restlessness, tremors, cough, headache, insomnia, lightheadedness, rash, runny nose, weakness, and weight gain. More serious and rare adverse reactions such as an increased risk of stroke and ministroke; neuroleptic malignant syndrome (NMS) which symptoms include fever, rigid muscles, confusion; tardive dyskinesia (TD) which symptoms include uncontrolled and abnormal movements of body parts.



Drug interaction

Inform your doctor about all prescribed and over-the-counter medications and herbal products you are taking and especially if you use alcohol, blood pressure drugs, carbamazepine, fluoxetine, ketoconazole, paroxetine, and quinidine.

Carbamazepine (Tegretol) decreases the levels of Abilifyole in the body stimulating the liver enzymes such as CYP3A4. Similar influence on Abilify is shown by phenytoin (Dilantin), rifampin (Rifadin, Rimactane, Rifadin, Rifater, Rifamate), and phenobarbital. Blocking of CYP3A4 by Ketoconazole (Nizoral) increases the amount of Abilify in the body. Other drugs with similar action are: itraconazole (Sporanox), fluconazole (Diflucan), voriconazole (Vfend), cimetidine (Tagamet), verapamil (Calan, Isoptin), diltiazem (Cardizem, Dilacor), erythromycin, clarithromycin (Biaxin), nefazodone (Serzone), ritonavir (Norvir), saquinavir (Invirase), nelfinavir (Viracept), indinavir (Crixivan), and grapefruit juice. Their action is not well studied though.

Quinidine (Quinaglute, Quinidex) inhibits another liver enzyme known as CYP2D6 and also is able to increase the levels of Abilify. Other medicines with similar action are fluoxetine (Prozac) and paroxetine (Paxil). Abilify may dangerously increase blood sugar levels in patients with diabetes.





Missed dose

Abilify is taken once daily, so take the missed dose as soon as you remember. If the next dose is within 12 hours, do not take the missed dose and resume your normal dosing schedule. Never double the dose this medication.



Overdose

Common adverse reactions include vomiting, somnolence, and tremor. Other clinically important signs and symptoms observed iare acidosis, aggression, aspartate aminotransferase increased, atrial fibrillation, bradycardia, coma, confusional state, convulsion, blood creatine phosphokinase increased, depressed level of consciousness, hypertension, hypokalemia, hypotension, lethargy, loss of consciousness, QRS complex prolonged, QT prolonged, pneumonia aspiration, respiratory arrest, status epilepticus, and tachycardia.



Storage

Store at room temperature in a tight dry container out of reach of children and pets. Do not use after expiration term.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Accutane

Other names used:

  • Roaccutane®

Active Ingredients:

  • Isotretionin

How does Accutane work and what pharmaceutical group does it belong to?

Isotretionin the active ingredient of Accutane belongs to a group of drugs called retinoids, which are used mainly in treatment of skin disorders. The exact mechanism of Accutane is not currently known however it is clinically determined that the drug exerts dose-dependent suppressive effect on the sebaceous glands activity and decreases their size. The drug also expresses anti-inflammatory effect on skin as well as inhibits the formation of comedones. The effects of the drug are temporary however the acne remissions may be controlled.

Which conditions are treated with Isotretinoin?

The drug is indicated in treatment of:

  • Severe cystic acne vulgaris
  • Acne rosacea
  • Hidradenitis suppurativa

What should a patient know before using Accutane?

The Isotretinoin should not be used in cases of:

  • Known hypersensitivity to any components of the preparation or to other retinoids
  • Pregnancy
  • Liver or renal failure
  • Vitamin A hypervitaminosis
  • Severe hyperlipidemia

Tell your doctor about the following if any apply to you:

  • You have relatives with increased levels of lipids in blood and are predisposed to hyperlipidemia
  • You or your relatives suffer from diabetes
  • You are suffering from Alcoholism
  • You are treating a depression

Which adverse effects may manifest when using the medication?

The side effects of Accutane include:

  • Vitamin A hypervitaminosis manifested in the following: dry skin and mucous membranes, haemorrhage in the nasal cavity, hoarseness, conjunctivitis and etc.
  • Skin problems: rash, itching, facial dermatitis, sweatiness, hyperpigmentation, reversible allopecia and etc.
  • Locomotor system: muscle pain, joint pain, hyperostosis, tendonitis
  • CNS: behavior changes, depression, headache, increased intracranial pressure, seizures
  • Sensory organs: decreased vision acuity, photosensibilisation, cataract, decreased hearing , keratitis
  • Gastrointestinal tract: nausea, colitis, GI hemorrhage, rarely hepatitis.
  • Respiratory organs: bronchospasm
  • Haemopoietic system: decreased leukocyte and erythrocyte levels, increase or decrease of thrombocyte levels
  • Immune system: local or systemic infections caused be gram-positive bacteria
  • Other: Hematuria, pancreatitis, vasculitis, lymphadenopathy

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Isotretinoin?

The drug is affected by the following:

  • Vitamin A supplements
  • Corticosteroids
  • Tetracycline antibiotics
  • Epilepsy treatment
  • Oral contraceptives
  • St.John's worth

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient: Accutane is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.