Generic Glucovance (Metformin/Glyburide)
Glucovance
Glucovance is a combination of two orally taken drugs possessing a hyproglycemic effect. Used to treat type 2 diabetes.
Package
Price
Per Pills
Savings
Bonus
Order
400/2.50 mg x 30 pills
$44.99
$1.50
$0.00
Next orders 10% discount
400/2.50 mg x 60 pills
$71.99
$1.20
$18.00
Next orders 10% discount
400/2.50 mg x 90 pills
$97.99
$1.09
$36.90
Next orders 10% discount
400/2.50 mg x 120 pills
$116.99
$0.97
$63.60
Next orders 10% discount
400/2.50 mg x 180 pills
$158.99
$0.88
$111.60
Next orders 10% discount
400/2.50 mg x 240 pills
$189.99
$0.79
$170.40
Next orders 10% discount
400/2.50 mg x 360 pills
$256.99
$0.71
$284.40
Next orders 10% discount
Free standard airmail service
Package
Price
Per Pills
Savings
Bonus
Order
500/5 mg x 30 pills
$46.99
$1.57
$0.00
Next orders 10% discount
500/5 mg x 60 pills
$75.99
$1.27
$18.00
Next orders 10% discount
500/5 mg x 90 pills
$101.99
$1.13
$39.60
Next orders 10% discount
500/5 mg x 120 pills
$122.99
$1.02
$66.00
Next orders 10% discount
500/5 mg x 180 pills
$165.99
$0.92
$117.00
Next orders 10% discount
500/5 mg x 240 pills
$198.99
$0.83
$177.60
Next orders 10% discount
500/5 mg x 360 pills
$268.99
$0.75
$295.20
Next orders 10% discount
Free standard airmail service
Product Description
Common use

Glucovance is a combination of two orally taken drugs possessing a hyproglycemic effect which belong to two different groups: metformin and glibenclamide. Metformin belongs to biguanide class of substances and decreases blood levels of glucose by increasity susceptibility of peripheral tissues to action of insulin. Metmorfin decreases absorption of carbohydrates in gastrointestinal tract and inhibits synthesis of glucose in the liver. Glibenclamide is a derivate of sulfonylurea and acts stimulating secretion of insulin by β-cells of the pancreas. It is used along with a diet and exercise program to to treat type 2 diabetes (non-insulin-dependent diabetes).



Dosage and direction

Take Glucovance twice daily with meals and full glass of water. Take it regularly and each time every day to get the best benefit from it.



Precautions

Avoid drinking alcoholic beverages during treatment with this medication. Notify your doctor first than to take Glucovance if you have any kind of fever, thyroid gland diseases with functional disorders, hypofunction of the anterior pituitary or the adrenal cortex. Inform your physician if you are pregnant or breastfeeding before to take this drug and also if you have severe breathing problems (e.g., obstructive lung disease, severe asthma), thyroid disease, blood problems (e.g., anemia, vitamin B-12 deficiency).



Contraindications

Hypersensitivity to metformin, glyburide, or other derivatives of sulfonylurea, type 1 diabetes, diabetic ketoacidosis, diabetic precoma, diabetic coma, kidney failure or kidney dysfunction, severe conditions which may lead to kidney dysfunction (dehydration, severe infection, shock), acute or chronic diseases that are accompanied by hypoxia of tissues: cardiac or respiratory failure, recent myocardial infarction,

hepatic impairment, porphyria, pregnancy, breast-feeding, co-administration with miconazole (anti-fungal), infectious diseases, extensive surgery, trauma, extensive burns and other conditions requiring a therapy with insulin, abnormal liver function, chronic alcoholism, acute alcohol intoxication, lactic acidosis, usage 48 hours before and 48 hours after the radioisotope or radiological examinations with help of iodinated contrast agents, in patients over 60 y.o., or doing hard physical work (risk of lactic acidosis increases), low glucose diet.



Side effects

The following side effects are most common and be rather severe to stop taking of the medication: swelling or rapid weight gain, nausea, vomiting, gas, bloating, diarrhea and loss of appetite. In case of lactic acidosis also get emergency medical help: shortness of breath, stomach pain, weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, feeling light-headed, and fainting. Allergic reaction is also possible: hives, swelling, rash.



Drug interaction

Cimetidine (Tagamet) increases blood levels of Glucophage affecting its metabolism. Glucophage is not compatible with alcohol. Concomitant administration with indirect anticoagulants and Cimetidine should be done with cautiousness. Glucophage enhances metabolism of Furosemide. Derivatives of sulfonylurea, insulin, acarbose, inhibitors of MAO, ACE inhibitors (such as captopril), oxytetracycline, cyclophosphamide and salicylates increase the effects of Glucophage. Decrease of hypoglycemic effect of Glucophage is caused by co-administration with thyroid medicines, birth control pills and other hormones, Epinephrine, Glucagon, thiazide diuretics, nicotinic acid derivates. Azole antifungals (fluconazole) also interact with Glucovance.



Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.



Overdose

Symptoms of Glucovance overdose are ones of low blood sugar: hunger, tremors, confusion, irritability, drowsiness, headache, weakness, sweating, fast heartbeat, seizure and have a source of sugar at hand always. If you experience one of them or any unusual symptoms call your doctor immediately.



Storage

Store at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Accutane

Other names used:

  • Roaccutane®

Active Ingredients:

  • Isotretionin

How does Accutane work and what pharmaceutical group does it belong to?

Isotretionin the active ingredient of Accutane belongs to a group of drugs called retinoids, which are used mainly in treatment of skin disorders. The exact mechanism of Accutane is not currently known however it is clinically determined that the drug exerts dose-dependent suppressive effect on the sebaceous glands activity and decreases their size. The drug also expresses anti-inflammatory effect on skin as well as inhibits the formation of comedones. The effects of the drug are temporary however the acne remissions may be controlled.

Which conditions are treated with Isotretinoin?

The drug is indicated in treatment of:

  • Severe cystic acne vulgaris
  • Acne rosacea
  • Hidradenitis suppurativa

What should a patient know before using Accutane?

The Isotretinoin should not be used in cases of:

  • Known hypersensitivity to any components of the preparation or to other retinoids
  • Pregnancy
  • Liver or renal failure
  • Vitamin A hypervitaminosis
  • Severe hyperlipidemia

Tell your doctor about the following if any apply to you:

  • You have relatives with increased levels of lipids in blood and are predisposed to hyperlipidemia
  • You or your relatives suffer from diabetes
  • You are suffering from Alcoholism
  • You are treating a depression

Which adverse effects may manifest when using the medication?

The side effects of Accutane include:

  • Vitamin A hypervitaminosis manifested in the following: dry skin and mucous membranes, haemorrhage in the nasal cavity, hoarseness, conjunctivitis and etc.
  • Skin problems: rash, itching, facial dermatitis, sweatiness, hyperpigmentation, reversible allopecia and etc.
  • Locomotor system: muscle pain, joint pain, hyperostosis, tendonitis
  • CNS: behavior changes, depression, headache, increased intracranial pressure, seizures
  • Sensory organs: decreased vision acuity, photosensibilisation, cataract, decreased hearing , keratitis
  • Gastrointestinal tract: nausea, colitis, GI hemorrhage, rarely hepatitis.
  • Respiratory organs: bronchospasm
  • Haemopoietic system: decreased leukocyte and erythrocyte levels, increase or decrease of thrombocyte levels
  • Immune system: local or systemic infections caused be gram-positive bacteria
  • Other: Hematuria, pancreatitis, vasculitis, lymphadenopathy

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Isotretinoin?

The drug is affected by the following:

  • Vitamin A supplements
  • Corticosteroids
  • Tetracycline antibiotics
  • Epilepsy treatment
  • Oral contraceptives
  • St.John's worth

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient: Accutane is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.